PCT Clomid Antiestrogen Raw Powder Clomifene Citrate CAS No:
50-41-9 Asaromatase Inhibitors
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Key words:Clomifene citrate,Clomifene
Clomid (clomiphene) is a non-steroidal fertility medicine. It
causes the pituitary gland to release hormones needed to stimulate
ovulation (the release of an egg from the ovary).
Clomid is used to cause ovulation in women with certain medical
conditions (such as polycystic ovary syndrome) that prevent
naturally occurring ovulation.
Clomid may also be used for purposes not listed in this medication
Clomid is a mixed estrogen agonist/antagonist (activator/blocker)
which, when bound to the estrogen receptor, puts it in a somewhat
different conformation (shape) than does estradiol. The estrogen
receptor requires binding of an estrogen or drug at its binding
site and also the binding of any of several cofactors at different
sites. Without the binding of the cofactor, the estrogen receptor
is inactive. Different tissues use different cofactors. Some of
these cofactors are able to bind to the estrogen receptor/Clomid
complex, but others are blocked due to the change in shape. The
result is that in some tissues Clomid acts as an antagonist - the
cofactor used in that tissue cannot bind and so the receptor
remains inactive - and in others Clomid acts as an agonist
(activator), because the cofactors used in that tissue are able to
Clomifene citrate (Clomid) Basic info.
Synonyms: Clomid; Clomiphene citrate
CAS NO: 50-41-9
Einecs No: 200-035-3
Appearance: white or milky white crystalline powder
Use: the goods to anti-estrogen fertility inducer, the objects in
dysfunctional uterine bleeding, polycystic ovary, menstrual
disorders and drug-induced amenorrhea and other gynecologic
Steroids Hormone Clomiphene Citrate/Clomid powders/CAS No: 50-41-9
Clomid is the anti-estrogen of choice for improving recovery of
natural testosterone production after a cycle, improving
testosterone production of endurance athletes, and is also
effective in reducing risk of gynecomastia during a cycle employing
Along with Nolvadex, Clomid is one of the two principal SERMs
(selective estrogen receptor modulators) used for enhanced recovery
of testosterone production after anabolic steroid cycles.
To understand how Clomid can aid this process, let’s look at how
natural testosterone production is regulated.
Testosterone production is regulated by a feedback loop which
senses not only testosterone or other androgen levels, but also
estrogen levels. This feedback loop includes the hypothalamus, the
pituitary, and the testes (often referred to as the HPTA, or
When the hypothalamus senses low estrogen levels and does not sense
high androgen levels, it’s stimulated to signal the pituitary by
producing more LHRH, which stands for LH releasing hormone. On
receiving this signal, the pituitary produces more LH (luteinizing
hormone) which in turn signals the testes to produce more
During an anabolic steroid cycle, high androgen levels shut this
process down entirely. If this is for only a relatively short
period such as 8 weeks, this is not a real issue. Over a longer
period of time, testicular atrophy might occur, however. That can
be avoided with HCG usage. Something that cannot be avoided,
however, is that the hypothalamus and pituitary respond not only
according to the hormone levels which they sense at a given moment,
but are affected in their response by their recent exposure. When
that exposure has been an extended period of anabolic steroid use,
responsiveness typically is poor even after anabolic steroid use
Clomid, as does Nolvadex, works by occupying the binding sites of
estrogen receptors of cells, without activating the receptors. This
reduces the extent to which estradiol can activate these receptors.
In the case of the hypothalamus, this leads to the hypothalamus
“concluding” that estrogen levels are low. If androgen levels are
not elevated, as indeed they should not be after an anabolic
steroid cycle, the hypothalamus is then stimulated to produce LHRH.
This will act to increase LH and restart natural testosterone
Clomid ordinarily is dosed at 50 mg/day. However, it’s important to
note that clomiphene has a long half life. Where this has relevance
is that when a daily dose is taken, the body will have not only
that dose in it, but also an accumulated amount of about five days’
worth of previous doses as well. That’s fine: it results in correct
blood levels. Where there can be a problem is when first starting
use. If simply taking 50 mg/day from the beginning, there is no
such buildup and levels will be low.
To account for this, 300 mg is taken on the first day, as three
doses of 100 mg, or optionally six doses of 50 mg. This immediately
gets levels to where they should be. Ongoing 50 mg/day dosing will
maintain this level.
After day 1, doses of more than 50 mg are not needed and are not
recommended. They will not improve results, but may increase
adverse side effects.
Adverse side effects of Clomid can include increased emotionalism
or vision disturbance. If vision disturbance is experienced, Clomid
should be discontinued immediately.
Clomid rarely leads to libido issues, which can be a problem with
Nolvadex. For this reason some prefer it to Nolvadex. Others, who
do not have that issue with Nolvadex, may prefer that drug. Both
are effective for restoring natural testosterone production. I have
a slightly better opinion of Clomid for effectiveness, but where a
person dislikes Clomid for emotional effects, or prefers Nolvadex
for any reason, Nolvadex is a perfectly acceptable substitute.
Clomid VS Nolvadex
Clomid differs from Nolvadex in that while SERMs are always
anti-estrogenic in some tissues, they are estrogenic in others.
Fortunately, both Clomid and Nolvadex are anti-estrogenic in the
hypothalamus, making them useful for post-cycle therapy (PCT), and
anti-estrogenic in breast tissue, making them useful as anti-gyno
agents. Clomid however is estrogenic in the pituitary, which in
some instances may even enhance its value for PCT. It’s likely
estrogenic to at least some other neurons in the brain as well,
causing increased emotionality. With regard to body fat and muscle,
or any observable physical property, Clomid and Nolvadex have no
other adverse estrogenic effects, but instead are useful
PCT with Clomid should begin as soon as androgen levels have
dropped to normal, and continue until confident that natural
testosterone production has been fully restored.
Clomid, properly, is a brand name: typically clomiphene citrate
products are used, but popularly called Clomid. Clomiphene citrate
is widely available both as a pharmaceutical and even more widely
as a research chemical, often in liquid form for oral use.
Clomid can and usually should be used as the only SERM in PCT. In
most instances, there is no point to combining with another SERM.
Where a second SERM such as Nolvadex is combined with Clomid, each
should be used at half dose rather than full dose. Using full dose
of each does not provide enhanced efficacy and only increases risk
of side effects.
Clomiphene citrate is the chemical name of active ingredient in
Clomid. Clomid is a registered trademark of Merrell Dow
Pharmaceuticals in the United States and/or other countries.
Clomid (clomiphene citrate) and post cycle therapy (PCT)
Question: When do I start Clomid?
Answer: When you start using your clomid all depends on what
steroids you were using during your cycle. Different steroids have
different half lifes and you should adjust your clomid intake
accordingly. As we have seen above, if we take clomid when the
androgen levels in our body is still high it will be a waste. We
need to wait for androgen levels to fall before implementing our
clomid therapy. However if we take it too late we could possibly
lose gains. Look at the list below to determine when you should
start clomid therapy. By selecting from the list all the steroids
you used in your cycle and which ever one has the latest starting
point then go with that. For example if I cycled dbol, sustanon and
winstrol I would use sustanon as it remains active in the body for
the longest period of time.
Anadrol/Anapolan: 8 - 12 hours after last administration
Deca: 3 weeks after last injection and clomid for 4 weeks
Dianabol: 4 - 8 hours after last administration
Equipoise: 3 weeks after last injection
Fina: 3 days after last injection
Primobolan depot: 10 - 14 days after last injection
Sustanon: 3 weeks after last injection
Testosterone Cypionate: 2 weeks after last injection
Testosterone Enanthate: 2 weeks after last injection
Testosterone Propionate: 3 days after last injection
Testosterone Suspension: 4 - 8 hours after last administration
Winstrol: 8 - 12 hours after last administration
Question: What is the most effective way for Clomid therapy.
Answer: Clomid has a long half life and as such there is no need to
split up doses throughout the day. I read some where that it was 5
days (any feedback on this). Now if we used sustanon and we start
using clomid 3 weeks after our last injection we anticipate that
androgen levels are low enough to start sending the correct
signals. If androgen levels are still a little high then the normal
50mgs/day of clomid for 1 week is not going to be effective. We
need to start at a high enough amount that will work or help even
if androgen levels are still a little high. 300mgs on day 1. I know
I said don’t split it up due to its long half life but try and
split this up 2 tabs 3 times a day. After we have finished this
first day we seek to use 100mgs for 10 days and then followed by
50mgs for 10 days.
Question: Do I need to use Clomid for 3 weeks?
Answer: Why don’t you want too? It is very cheap, very effective
and can mean the difference between maintaining gains and losing
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